Nature, Volume 454Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
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Page 173
... myeloma - cell death . As myeloma is a slow - growing tumour , it has been proposed12 that myeloma cells are differ- entiated descendants of transformed B cells , which would be the myeloma progenitor cells . IRF4 is inactive in B cells ...
... myeloma - cell death . As myeloma is a slow - growing tumour , it has been proposed12 that myeloma cells are differ- entiated descendants of transformed B cells , which would be the myeloma progenitor cells . IRF4 is inactive in B cells ...
Page 226
... myeloma can extend survival but are not curative39 . Hence , new therapeutic strategies are needed that tar- get molecular pathways shared by all subtypes of myeloma . Here we show , using a loss - of - function , RNA - interference ...
... myeloma can extend survival but are not curative39 . Hence , new therapeutic strategies are needed that tar- get molecular pathways shared by all subtypes of myeloma . Here we show , using a loss - of - function , RNA - interference ...
Page 230
... myeloma ↑↑ IRF4 ↑↑ MYC BLIMP - 1 IRF4 ↑ MYC IRF4 multiple myeloma programme Cell cycle regulation DUSP5 CDKN1B E2F5 STAG2 CDK6 MYC AMPD1 Metabolism PIM2 MYC and energyPHKA1 SLC37A4 General SUB1 ELL2 transcription CCNC AMPD1 CCNC ...
... myeloma ↑↑ IRF4 ↑↑ MYC BLIMP - 1 IRF4 ↑ MYC IRF4 multiple myeloma programme Cell cycle regulation DUSP5 CDKN1B E2F5 STAG2 CDK6 MYC AMPD1 Metabolism PIM2 MYC and energyPHKA1 SLC37A4 General SUB1 ELL2 transcription CCNC AMPD1 CCNC ...
Contents
More CO2 means more | 46 |
ARTICLES | 49 |
SMAD proteins control DROSHAmediated microRNA maturation | 56 |
Copyright | |
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