The Missing Gene: Psychiatry, Heredity, and the Fruitless Search for GenesGenetic research in psychiatry has reached the crisis stage due to the continuing failure to identify the genes presumed to cause many of today's most troubling mental disorders. Dr. Joseph presents a clearly argued explanation for this failure, and warns that by focusing on the wrong goal, precious resources are diverted from the search for real causes and treatments. We were supposed to have discovered the genes that cause mental disorders by now; but we have not. Unfortunately, researchers and reviewers almost never consider the possibility that genes for the major psychiatric conditions have not been identified for one insuperable reason: they do not exist. At bottom, the search for genes in psychiatry is based on the uncritical acceptance of the results of family, twin and adoption studies. Professionals, students and the public must be informed that these studies do not provide scientifically acceptable evidence in support of genetics. What causes psychological distress? Are we shaped primarily by our environment or by our genes? These very old questions remain controversial. Quantitative genetic tests such as family, twin and adoption studies have laid the foundations for the current worldwide effort to identify the genes presumed to underlie psychiatric disorders such as schizophrenia, bipolar disorder, A.D.H.D., autism and so on. This book argues that molecular genetic researchers take a hard second look at these foundations, which are far weaker than they believe. This book is urgently needed. The results of genetic research have a profound effect on both scientific and public thinking, as well as on social policy decisions. This book presents an alternative view to the one that currently dominates psychiatry and psychology. The author calls for a paradigm shift in psychiatry away from genetic explanations of mental disorders, and towards a greater understanding of how family, social and political environments contribute to human psychological distress. This book is destined to play an important role in this shift. Like The Gene Illusion, it will be a controversial book and is sure to spark intense discussion. |
Contents
1 | |
5 | |
7 | |
9 | |
37 | |
Chapter 3 A Critique of the Spectrum Concept as Used in the DanishAmerican Schizophrenia Adoption Studies | 59 |
Chapter 4 Pellagra and Genetic Research | 87 |
Psychiatry and Psychology Textbooks Inaccurate Accounts of Schizophrenia Adoption Research | 97 |
Table of Contents | vii |
Foreword | 1 |
Authors Preface | 5 |
List of Abbreviations | 7 |
Science or Pseudoscience? | 9 |
Activity Deserving of Attention or Studies Disordered by Deficits? | 37 |
Chapter 3 A Critique of the Spectrum Concept as Used in the DanishAmerican Schizophrenia Adoption Studies | 59 |
Chapter 4 Pellagra and Genetic Research | 87 |
A Primary Source for Misunderstanding the Genetics of Schizophrenia | 115 |
Much Ado About Very Little | 153 |
Chapter 8 The 1942 Euthanasia Debate in the American Journal of Psychiatry | 173 |
A Critical Review of the Equal Environment Assumption Test Literature | 181 |
Chapter 10 Bipolar Disorder and Genetics | 203 |
Chapter 11 Genotype or Genohype? The Fruitless Search for Genes in Psychiatry | 221 |
Glossary | 265 |
273 | |
Acknowledgments | 309 |
Index of Names | 311 |
Index of Subjects | 315 |
The Missing Gene | iii |
The Missing Gene | v |
Psychiatry and Psychology Textbooks Inaccurate Accounts of Schizophrenia Adoption Research | 97 |
A Primary Source for Misunderstanding the Genetics of Schizophrenia | 115 |
Much Ado About Very Little | 153 |
Chapter 8 The 1942 Euthanasia Debate in the American Journal of Psychiatry | 173 |
A Critical Review of the Equal Environment Assumption Test Literature | 181 |
Chapter 10 Bipolar Disorder and Genetics | 203 |
Chapter 11 Genotype or Genohype? The Fruitless Search for Genes in Psychiatry | 221 |
Glossary | 265 |
273 | |
Acknowledgments | 309 |
311 | |
321 | |
Other editions - View all
The Missing Gene: Psychiatry, Heredity, and the Fruitless Search for Genes Jay Joseph Limited preview - 2006 |
The Missing Gene: Psychiatry, Heredity, and the Fruitless Search for Genes Jay Joseph Limited preview - 2006 |
The Missing Gene: Psychiatry, Heredity, and the Fruitless Search for Genes Jay Joseph Limited preview - 2006 |
Common terms and phrases
ADHD adoption research adoption studies adoptive parents association autism Behavior Genetics bipolar disorder caused Chapter claims conclusions concordance rate correlation critical Danish-American diag diagnosed with schizophrenia difference discussed disease DZ twins environmental factors equal environment assumption eugenic evidence family studies Faraone favor of genetics find genes Folstein fraternal twins Gene Illusion genetic basis genetic factors genetic influences genetic theories Gottesman half-siblings heritability hyperactivity Ibid identical and fraternal identical twins identical versus fraternal index adoptees investigators Joseph Kallmann Kendler Kety and colleagues linkage Mendlewicz molecular genetic molecular genetic research offspring pellagra phrenia probands psychiatric disorders psychiatric geneticists psychiatric genetics psychological racial hygiene reported risk Rosenthal Rüdin Rutter schizo schizophrenia schizophrenia adoption schizophrenia spectrum siblings similar environments social statistically significant support of genetic textbooks trait trait-relevant Tsuang twin method twin pairs twin researchers twin studies twins experience Wender wrote zygosity
Popular passages
Page 282 - BA (1976). The inheritance of affective disorders: A review of data and of hypotheses.
Page 282 - Gjone, H., Stevenson, J., & Sundet, JM (1996). Genetic influence on parentreported attention-related problems in a Norwegian general population twin sample.
Page 278 - Comings DE, Gade-Andavolu R, Gonzales N, et al: Comparison of the role of dopamine, serotonin, and noradrenaline genes in ADHD, ODD and conduct disorder: multivariate regression analysis of 20 genes. Clin Genet 57: 1 78196, 2000 Gönners CK: A teacher rating scale for use in drug studies with children.