Introduction to Pharmaceutical Chemical AnalysisThis textbook is the first to present a systematic introduction to chemical analysis of pharmaceutical raw materials, finished pharmaceutical products, and of drugs in biological fluids, which are carried out in pharmaceutical laboratories worldwide. In addition, this textbook teaches the fundamentals of all the major analytical techniques used in the pharmaceutical laboratory, and teaches the international pharmacopoeias and guidelines of importance for the field. It is primarily intended for the pharmacy student, to teach the requirements in “analytical chemistry” for the 5 years pharmacy curriculum, but the textbook is also intended for analytical chemists moving into the field of pharmaceutical analysis.
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Contents
International Pharmacopoeias Regulations and Guidelines | 13 |
Fundamental Chemical Properties Buffers and | 23 |
Fundamentals of Pharmaceutical Analysis | 33 |
Titrimetric Methods | 65 |
Introduction to Spectroscopic Methods | 83 |
UV Spectrophotometry | 89 |
8 | 103 |
Atomic Spectrometry | 115 |
Capillary Electrophoresis | 211 |
Mass Spectrometry | 231 |
17 | 261 |
18 | 273 |
19 | 299 |
20 | 309 |
21 | 327 |
Chemical Analysis of Final Pharmaceutical Products | 405 |
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Common terms and phrases
absorbance absorption according acid active pharmaceutical ingredient added addition amount analysis analyte applied aqueous atoms calculated called capillary Chapter charged chemical chromatography column components compounds concentration containing corresponding derivatization detection detector determined dilute discussed dissolved drug electron elution example extraction Figure final flow given gives groups HPLC ibuprofen identification important impurities increases injection interactions internal ionization ions limit liquid mass means measured method mixture mobile phase molecular molecules monographs normally obtained organic paracetamol particles peak performed pharmaceutical placed plate polar preparation present principle procedure proteins provides quantitative radiation range raw material reaction reference relatively requirements retention sample sample solution selected separation shown silica solubility solution solvent specific spectra spectrometer spectrum standard stationary phase substances Table tablets technique temperature titration typically volume wavelength weight