Microbial Biochemistry

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Springer Science & Business Media, Mar 19, 2013 - Computers - 333 pages
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Microbial physiology, biochemistry, and genetics allowed the formulation of concepts that turned out to be important in the study of higher organisms.
In the first section, the principles of bacterial growth are given, as well as the description of the different layers that enclose the bacterial cytoplasm, and their role in obtaining nutrients from the outside media through different permeability mechanism described in detail. A chapter is devoted to allostery and is indispensable for the comprehension of many regulatory mechanisms described throughout the book.
Another section analyses the mechanisms by which cells obtain the energy necessary for their growth, glycolysis, the pentose phosphate pathway, the tricarboxylic and the anaplerotic cycles. Two chapters are devoted to classes of microorganisms rarely dealt with in textbooks, namely the Archaea, mainly the methanogenic bacteria, and the methylotrophs. Eight chapters describe the principles of the regulations at the transcriptional level, with the necessary knowledge of the machineries of transcription and translation.

The next fifteen chapters deal with the biosynthesis of the cell building blocks, amino acids, purine and pyrimidine nucleotides and deoxynucleotides, water-soluble vitamins and coenzymes, isoprene and tetrapyrrole derivatives and vitamin B12.
The two last chapters are devoted to the study of protein-DNA interactions and to the evolution of biosynthetic pathways. The considerable advances made in the last thirty years in the field by the introduction of gene cloning and sequencing and by the exponential development of physical methods such as X-ray crystallography or nuclear magnetic resonance have helped presenting metabolism under a multidisciplinary attractive angle.

The level of readership presupposes some knowledge of chemistry and genetics at the undergraduate level. The target group is graduate students, researchers in academia and industry.

 

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Contents

The outer membrane of Gram
7
Penicillin sensitivity
13
Allosteric enzymes
31
An alternative model
37
Glycolysis gluconeogenesis
39
The pentose phosphate
45
16
63
The Archaea
71
27
197
Biosynthesis of alanine
199
Biochemical function of the selenocysteine resi
208
29
224
The biosynthesis of histidine
225
117
231
The biosynthesis of purine nucleotides
239
The biosynthesis
245

B Methylotrophs
82
Constitutive mutants
89
Transcription
97
Isolation of the Lac repressor
104
Enzyme repression in anabolic
111
The ribosomes
119
Attenuation
127
How biosynthetic pathways
135
The synthesis of dipicolinic acid a substance
142
Biosynthesis of methionine from homoserine
143
Summary of the biosynthetic pathway of
149
The binding of pyridine nucleotides to aspar
156
Multifunctional proteins
162
19
165
The regulation of isoleucine synthesis at
168
25
172
Biosynthesis of the amino
177
The biosynthesis of glutamate
184
The biosynthesis of lysine in yeasts
191
The synthesis of deoxyribonucleoside triphos
251
Biosynthesis of nicotinamide NAD
257
Biosynthesis of carotene
271
30
274
Biosynthesis of
279
A type of chromatic adaptation under condi
286
Interactions between
295
60
302
Evolution of biosynthetic
303
63
312
Transmembrane facilitators
316
31
317
64
323
118
324
217
328
76
329
142
331
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