danger of the drug, and after several applications, she became careless, and applied more freely than usual on one occasion. In a few minutes she became giddy and intoxicated as she expressed it, and which was soon followed by a feeling of approaching death, but she soon recovered after taking some whisky.

I should suppose from her statement, that she used about one-half grain of the drug. She is a stout, healthy lady, weighs about 160 pounds, and is free from any organic lesion.

Three white patients suffered light attacks of collapse during circumcision, two of which had taken whisky before the operation as a preventive.

In fifteen operations, ten colored and five white, I used 20 to 30 minims of a 4 per cent. sol., which I injected around the penis after having it bound tightly with a rubber cord. With the colored patients I had no trouble, but as stated above, three of the white patients were poisoned. The cord in each case was sufficiently tight to prevent a flow of arterial blood, but the cocaine in the three cases referred to, got into the circulation, as was evident from the symptoms.

I do not think one grain is a safe dose to give promiscuously, as recommended by Dr. Callis of Dyer. I do not think that the cases of cocaine poisoning reported by Quinn, Knapp, Huese and other ophthalmic surgeons,should be forgotten when we have a patient to swallow one or two grains of the drug, or perhaps may use same amount hypodermatically, although there seems to be a slight difference if any, between the toxic symptoms, when given one way or the other.

I suppose the clotting of the blood produced by the latter method retards its entrance to the circulation, whilst it being readily absorbed by the stomach gives it a quick entrance to the system, thus making the time between giving the drug and first appearance of poisonous symptoms about the same in both methods. Very respectfully, w. F. ROCHELLE, M.D. Jackson, Tenn., February 19, 1890.

Miscellaneous Selections.

Approved Remedies in the Treatment of Acute Epidemic Bronchitis (Influenza).

Accumulated experience with the epidemic,familiarly known as "la grippe," has already afforded ample opportunity to correctly gauge the efficiency of various modes of treatment suggested, and establish the value of different remedies employed to correct the abnormal symptoms. Of those which have proven themselves most useful, Parke, Davis & Co. call attention to some combinations which are especially adapted to meet the prominent indications.

The catarrhal affections of the respiratory mucous membrane resolve themselves into several distinct phases: 1. Bronchial catarrh. This is alleviated by the employment of the following formula, for which we have selected the name of "syrup white pine compound." Each fluidounce repre

One of the most marked indications for treatment is to restore the dry mucous membrane to a condition of normal secretion, to overcome the interference with respiration by stimulating the respiratory centers, and to allay the inflammation and irritation by sedatives and demulcents.

The formula which we offer under the name of bronchial sedative has also been found admirably adapted for meeting the threefold indications specified. It has been widely used in the hospitals of this country and Europe, as well as in private practice. It is palatable and readily taken by children, and more faithfully by adults than the nauseous expectorant mixtures so often given. Unlike the latter, it does not inter

fere with digestion, and may be administered as required without developing any untoward symptoms. The physician will, of course, modify the formula and dose, when necessary, to meet the requirements of the individual case.

Each fluidounce contains:

Ammonium chloride, .

Fluid tolu, soluble,

Fluid opium, camphorated,

30 grains.

8 minims.

4 minims.

Elixir licorice, aromatic, q s., ad. 1 fluidounce.

Nasal catarrh of a pronounced and persistent type is usually associated with conjunctivitis. As there is certainly here an inter-dependence between the nasal and conjunctival catarrhs, the alleviation of the former is coincident with the disappearance of the latter. To remove the inflammation and reduce the discharge, the union of antiseptics and palliatives in "nasal tablets" as prepared by us after the formula of Dr. Carl Seiler, will be found of service. Each tablet contains:

One tablet dissolved in from two to four ounces of warm water will form a satisfactory solution for general use.

Among other preparations now announced by Parke, Davis & Co. as being in strong demand are pichi (Fabiana imbricata), quinine muriate pills, D'Ary's cascara compound pellets, and hemoglobin compound. According to the experience of physicians who have tested pichi chemically, it is especially efficacious in diseases of the urinary apparatus and of the liver. In cases of vesical catarrh, acute or chronic, dependent upon mechanical cause, such as gravel or calculus, or a uric acid. diathesis, this remedy will quickly modify the urinary secretions, calm the irritability, and favor the expulsion of all gravel and calculi that can be passed through the urethra.

It favorably modifies also chronic purulent mucous secretions. Its action on affections of the liver must be attributed to its diuretic properties. It is recommended for icterus, hydropsy, and dyspepsia due to insufficient biliary secretions. In this case the essential oil, when absorbed and carried into circulation, acts like a stimulant of the secretory apparatus in general; but the specific action of pichi is directed without doubt upon the organs of the urinary apparatus. It is used in the shape of a fluid extract, in doses of from 4 to 6 teaspoonfuls per day in cold water or warm.

Muriate of quinine pills are regarded now as one of the most eligible forms of administering quinine. These pills are highly soluble, and secure rapid absorption and the speedy therapeutic results of this drug.

D'Ary's cascara compound pellets were originally suggested by Dr. Ralph D'Ary in 1885, and since then have been widely used in constipation and with the result of radical cure of this widespread affection in most cases. The formula is as

In an article published in Medical World, February, 1890, by F. E. Stewart, M.D., PH.G., this author calls attention to the value of hemoglobin compound* or bullock's blood in therapeutics. He reports the experience of many physicians who have employed successfully its stimulant nutrient properties in cases in which all other forms of nutrients are rejected. It is evident from the experience had with this preparation that it has been of the greatest service in acute diseases in securing assimilation and restoring vitality when the stomach is irritable or its functions more or less inoperative.

* As made by Parke, Davis & Co.

Campho-Phenique vs. Iodoform-A Practical Note."

It is not the purpose of this paper to discuss the value of the two drugs in a general way, but merely to call the attention of the profession to a certain practical point wherein the author has found Campho-Phenique a superior to iodoform. The many defects that have recently been pointed out accompanying the use of iodoform are so well known to all that I need not recount them. I will mention that the hopes which were originally entertained by many in regard to a certain mysterious constitutional action of the iodoform in tubercular and syphilitic diseases have been entirely dissipated by long and careful experimentation with that chemical. The fact that the use of iodoform in most of the European and American hospitals has decreased largely during the past five years is apparent to all observers.

When Campho-Phenique was first shown to me and I was told that it consisted of fifty-one parts of pure carbolic acid and forty-nine of camphor, and that it was a non-irritant and could be used on mucous surfaces, for instance on the tongue, in its pure state without causing pain, I was very skeptical. A few tests made on my own person convinced me that the preparation was in many respects unique, and I began to use it in superficial wounds and minor operations as a dressing. The powerful antiseptic effect of the Campho-Phenique, knowing its composition, required no special proof, since the antiseptic powers of carbolic acid in much weaker solutions has been demonstrated beyond error. The fact, however, that a fifty per cent. solution of carbolic acid could be employed on the skin and on wounds without caustic and escharotic effects was a striking and remarkable one, knowing that this strength of a watery or glycerine solution of the same substance caused unbearable burning pain and destruction of tissues.

The tendency of modern surgery has been toward the discovery of methods of wound treatment by means of which the healing process may take place with as little disturbance to the diseased part as possible. Thus the Dauerverband of

* From Medical Mirror for February, 1890, by A. C. Bernays, A.M., M.D., Professor of Anatomy, St. Louis College of P. and S.