Handbook of Pharmaceutical Granulation TechnologyDilip M. Parikh Integrating the basic principles and industrial practices of pharmaceutical granulation production, this book discusses technologies and demonstrates cost-effective approaches to manufacturing solid-dosage forms with content uniformity and consistent physical properties while complying with regulatory requirements. Specialists from pharmaceutical companies, academia, and the U.S. Drug Regulatory Affairs agency address current and changing practices in industrial drug granulation production. Text, charts, figures, and photographs illustrate the pros and cons of diverse methods and technologies for accurately achieving strong bonding of particles in tablets and capsules. |
Contents
INTRODUCTION | 26 |
Drug Substance and Excipient Characterization | 29 |
SOLUBILITY | 39 |
CRYSTAL PROPERTIES AND POLYMORPHISM | 46 |
4 | 60 |
Binders and Solvents | 61 |
FACTORS INFLUENCING BINDER EFFICIENCY | 67 |
| 75 | |
Batch Fluid Bed Granulation | 227 |
SinglePot Processing | 303 |
ExtrusionSpheronization as a Granulation Technique | 333 |
Continuous Granulation | 369 |
Sizing of Granulation | 389 |
Methods and Significance | 419 |
Bioavailability and Granule Properties | 471 |
INTRODUCTION | 484 |
Common terms and phrases
agglomerates atomization batch binder solution bioavailability blade blend bowl bulk density changes characterization chopper cleaning compactor deaeration Dev Ind Pharm dicalcium phosphate disintegration dissolution dosage form droplet Drug Dev Ind dryer effect equipment excipients extrudate feed screw filters flow fluid bed granulation fluid bed processor fluidized bed force formulation friability gran granulation process granule growth high shear mixer impeller speed increase Int J Pharm lactose liquid addition liquid binder manufacturing mean granule mechanical method methylcellulose microcrystalline cellulose microwave milling mixing moisture content nozzle operation particle size distribution pellets Pharm Sci Pharm Technol porosity powder power consumption pressure process variables properties reduced roll roller compaction rotating scale-up screen sieve sieve analysis single-pot processors solid solubility solvent spheres spheronization spray drying spray-drying starch strength tablet techniques temperature tensile strength vacuum deaeration viscosity wet granulation wet massing