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Being the Prize Essay to which the Medical Society of London awarded the

Fothergillian Gold Medal for mdccclii.

BY

FREDERICK WILLIAM HEADLAND, M.B., B.A., F.L.S.,

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JOHN CHURCHILL, NEW BURLINGTON STREET.
MACLACHLAN AND STEWART, EDINBURGH ;

FANNIN AND CO., DUBLIN.

MDOCCLV.

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The Author reserves to himself the right of translating this

Work.

JOHN EDWARD TAYLOR, PRINTER,
LIITLE QUEEN STREET, LINCOLN'S INN FIELDS.

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PREFACE

TO THE SECOND EDITION.

The first edition of this Essay having been for some time

out of print, the Author has been encouraged to hope that a second issue may meet with a favourable reception. He has been at some pains to make such additions to the present volume as seemed to be necessitated by the rapid advance of therapeutic science, at the same time that he has felt the necessity of not increasing its bulk to an inconvenient extent. The first and second chapters have been left unaltered, but some new articles will be found scattered through the third and fourth chapters, and some additional observations and experiments recorded in the same.

The Author has derived much instruction from a perusal of the various reviews of his Essay, in English and American periodicals. He is especially indebted to Dr. Maclagan, of

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