Fluorine and Health: Molecular Imaging, Biomedical Materials and PharmaceuticalsAlain Tressaud, Gunter Haufe Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms.Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics |
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Fluorine and Health: Molecular Imaging, Biomedical Materials and Pharmaceuticals Alain Tressaud,Günter Haufe No preview available - 2008 |
Common terms and phrases
18F-labeled 18F]fluoride 19F NMR activity agents amine amino acids analogues apatite applications assessment binding bioceramics Biol biological Biomaterials blood bone brain calcium cancer caries cells Chem chemical shift chemistry Clin clinical Compds Radiopharm compomers compounds Dent dental dental caries dental fluorosis detection disease drug electrophilic emulsion enamel enzyme evaluation fluorapatite fluoride intake fluoride ions fluorinase fluorine atoms fluorine-18 fluoroolefin fluorosis glass-ionomers hydrogen bonds hydrophobic hypoxia imaging inhibition inhibitors interactions isosteres Label ligands lung metabolism metastases molecular molecules monoamine oxidase myocardial Nucl nucleophilic OH OH oxygen patients peptide perfluorocarbon phosphate plasma positron emission tomography potential properties prostaglandin prostanoids protein R.P. Mason radiochemical yield radioligand radiopharmaceuticals reaction reagents receptor reported resonance Scheme sensitivity silicone oil solubility specific structure studies substitution substrate surface synthesis therapy tion tissue tracer treatment tumor uptake vitro vivo


