Nature, Volume 428Sir Norman Lockyer Macmillan Journals Limited, 2004 - Electronic journals |
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Page 190
... Skp2 is an oncoprotein that often shows increased expression in human cancers2 ; however , the mechanism that regulates its cellular abundance is not well understood . Here we show that both Skp2 and Cks1 proteins are unstable in G1 and ...
... Skp2 is an oncoprotein that often shows increased expression in human cancers2 ; however , the mechanism that regulates its cellular abundance is not well understood . Here we show that both Skp2 and Cks1 proteins are unstable in G1 and ...
Page 192
... Skp2 ( AF ) a Control 0 2 4 6 9 12 % of. d Skp2 Cdh1 a WT D - box I mutant D - box III mutant D - box II mutant D - box IV mutant Skp2 ( 145 ) Skp2 ( 194 ) Skp2 ( AF ) Skp2 + Cdh1 Skp2 + Cdc20 Cdc20 e Cdh1 ( anti - HA ) b Skp2 WT mutant ...
... Skp2 ( AF ) a Control 0 2 4 6 9 12 % of. d Skp2 Cdh1 a WT D - box I mutant D - box III mutant D - box II mutant D - box IV mutant Skp2 ( 145 ) Skp2 ( 194 ) Skp2 ( AF ) Skp2 + Cdh1 Skp2 + Cdc20 Cdc20 e Cdh1 ( anti - HA ) b Skp2 WT mutant ...
Page 195
... Skp2 p27 Cdc20. 1 for ubiquitin in these reactions ( Fig . 2c ) . Collectively , these data indicate that APCCDHI can polyubiquitinate Skp2 in a D - box- dependent manner . To investigate whether APCCDH1 is a major regulator of Skp2 in ...
... Skp2 p27 Cdc20. 1 for ubiquitin in these reactions ( Fig . 2c ) . Collectively , these data indicate that APCCDHI can polyubiquitinate Skp2 in a D - box- dependent manner . To investigate whether APCCDH1 is a major regulator of Skp2 in ...
Contents
Ecologists highlight | 19 |
journal editors on the spot | 25 |
Sequencing | 38 |
Copyright | |
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activity analysis antibody apoptosis applications assays atom Biol biology Bmi1 boson cancer Cdh1 cell biology Centre China Chlb chromosome Cks1 clinical cloned complex culture cyclin cyclin E density disease domain drug e-mail effects experience Ferroplasma follicle fracture function funding gene expression genetic genome glms hCDC4 Higgs boson human increase indicated infection ING4 Institute interactions kinetochores Laboratory macrophage mice microtubules molecular mucus mutations myocardin Nature nature publishing group Naturejobs neurons NF-kB observed ocean oocytes ovaries phase photon Phys polar population postdoctoral prion probe production protein PSI+ qubit rapamycin receptor recombination region ribozyme rld1 RNA interference scientific scientists sequence signal siRNA Skp2 species stem cells strains structure Supplementary Fig surface target temperature transfected tubulin tumour University wild-type yeast