Nature, Volume 428Sir Norman Lockyer Macmillan Journals Limited, 2004 - Electronic journals |
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Page 79
... Cyclin E a - Tubulin RT + RT + RT + RT + RT + - e HSG HCT116 + / + + / + + / + + / + - / - - / - Cyclin E a - Tubulin DLD - 1 + / + - / - - / - hCDC4 genotype + + hCDC4 siRNA Cyclin E siRNA Control siRNA a b C g d e f h j k Figure 2 ...
... Cyclin E a - Tubulin RT + RT + RT + RT + RT + - e HSG HCT116 + / + + / + + / + + / + - / - - / - Cyclin E a - Tubulin DLD - 1 + / + - / - - / - hCDC4 genotype + + hCDC4 siRNA Cyclin E siRNA Control siRNA a b C g d e f h j k Figure 2 ...
Page 80
... Cyclin E is the only known target of the ubiquitin ligase activity of hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin ...
... Cyclin E is the only known target of the ubiquitin ligase activity of hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin ...
Page 191
... cyclin A and cyclin B and the disappearance of phosphorylation on Ser 10 of histone H3 ( Fig . 2a ) . By contrast , silencing of Cdc20 delayed mitotic exit by about 1h ( data not shown ) . Second , cyclin A and cyclin B are normally ...
... cyclin A and cyclin B and the disappearance of phosphorylation on Ser 10 of histone H3 ( Fig . 2a ) . By contrast , silencing of Cdc20 delayed mitotic exit by about 1h ( data not shown ) . Second , cyclin A and cyclin B are normally ...
Contents
Ecologists highlight | 19 |
journal editors on the spot | 25 |
Sequencing | 38 |
Copyright | |
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activity analysis antibody apoptosis applications assays atom Biol biology Bmi1 boson cancer Cdh1 cell biology Centre China Chlb chromosome Cks1 clinical cloned complex culture cyclin cyclin E density disease domain drug e-mail effects experience Ferroplasma follicle fracture function funding gene expression genetic genome glms hCDC4 Higgs boson human increase indicated infection ING4 Institute interactions kinetochores Laboratory macrophage mice microtubules molecular mucus mutations myocardin Nature nature publishing group Naturejobs neurons NF-kB observed ocean oocytes ovaries phase photon Phys polar population postdoctoral prion probe production protein PSI+ qubit rapamycin receptor recombination region ribozyme rld1 RNA interference scientific scientists sequence signal siRNA Skp2 species stem cells strains structure Supplementary Fig surface target temperature transfected tubulin tumour University wild-type yeast