Nature, Volume 428Sir Norman Lockyer Macmillan Journals Limited, 2004 - Electronic journals |
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Page 78
... cyclin E were used to reconstruct the spatial relationship between the two proteins , 9 . All but one of the missense mutations occurred in the WD40 domain repeats in the 3 ' region of the gene , and many resulted in the elimination of ...
... cyclin E were used to reconstruct the spatial relationship between the two proteins , 9 . All but one of the missense mutations occurred in the WD40 domain repeats in the 3 ' region of the gene , and many resulted in the elimination of ...
Page 79
... cyclin E protein ( Fig . 2d ) and a higher percentage of micronuclei formation as compared with parental cells ... Cyclin E a - Tubulin Cyclin E -1- RT HSG HCT116 DLD - 1 + / + + / + + / + - / - - / - + / + - / - - / - hCDC4 genotype ...
... cyclin E protein ( Fig . 2d ) and a higher percentage of micronuclei formation as compared with parental cells ... Cyclin E a - Tubulin Cyclin E -1- RT HSG HCT116 DLD - 1 + / + + / + + / + - / - - / - + / + - / - - / - hCDC4 genotype ...
Page 80
... Cyclin E is the only known target of the ubiquitin ligase activity of hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin E ...
... Cyclin E is the only known target of the ubiquitin ligase activity of hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin E ...
Contents
of genetically modified grain | 8 |
Just | 14 |
Medical editors urged to accept ethical code | 17 |
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activity analysis antibody apoptosis applications assays atom Biol biology boson cancer candidates Cdh1 cell biology Centre China Chlb chromosome Cks1 clinical cloned complex culture cyclin cyclin E density disease domain drug e-mail effects experience Ferroplasma follicle function funding gene expression genetic genome GlcN6P hCDC4 Higgs boson human increase indicated infection ING4 Institute interactions kinetochores Laboratory mice microtubules molecular molecules mucus mutations myocardin Nature nature publishing group Naturejobs neurons observed ocean oocytes ovaries phase photon Phys polar population postdoctoral prion probe production protein PSI+ qubit rapamycin receptor recombination region riboswitches ribozyme rld1 RNA interference role scientific scientists sequence signal siRNA Skp2 species stem cells strains structure Supplementary Fig surface target temperature transfected tubulin tumour University wild-type yeast