Nature, Volume 428Sir Norman Lockyer Macmillan Journals Limited, 2004 - Electronic journals |
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Page 78
... hCDC4 is genetically altered , its coding exons were amplified by polymerase chain reaction ( PCR ) from 190 colorectal tumours and sequenced . Somatic mutations in the hCDC4 gene were found in 22 of the 190 samples . Nonsense mutations ...
... hCDC4 is genetically altered , its coding exons were amplified by polymerase chain reaction ( PCR ) from 190 colorectal tumours and sequenced . Somatic mutations in the hCDC4 gene were found in 22 of the 190 samples . Nonsense mutations ...
Page 79
... hCDC4 gene in DLD - 1 , another karyotypically stable colorectal cancer cell line . We obtained a clone in which both alleles were disrupted ( Fig . 2b , c ) , and the phenotype of this clone hCDC4 HE Z 3 ' NeopA -4.2 kb P 5 ' Neo -2.0 ...
... hCDC4 gene in DLD - 1 , another karyotypically stable colorectal cancer cell line . We obtained a clone in which both alleles were disrupted ( Fig . 2b , c ) , and the phenotype of this clone hCDC4 HE Z 3 ' NeopA -4.2 kb P 5 ' Neo -2.0 ...
Page 80
... hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin E in DLD - 1 and HSG cells through transient transfection . An ...
... hCDC4 . To determine whether the increased abundance of cyclin E was sufficient to reproduce the phenotype observed on inactivation of hCDC4 , we overexpressed cyclin E in DLD - 1 and HSG cells through transient transfection . An ...
Contents
of genetically modified grain | 8 |
Just | 14 |
Medical editors urged to accept ethical code | 17 |
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activity analysis antibody apoptosis applications assays atom Biol biology boson cancer candidates Cdh1 cell biology Centre China Chlb chromosome Cks1 clinical cloned complex culture cyclin cyclin E density disease domain drug e-mail effects experience Ferroplasma follicle function funding gene expression genetic genome GlcN6P hCDC4 Higgs boson human increase indicated infection ING4 Institute interactions kinetochores Laboratory mice microtubules molecular molecules mucus mutations myocardin Nature nature publishing group Naturejobs neurons observed ocean oocytes ovaries phase photon Phys polar population postdoctoral prion probe production protein PSI+ qubit rapamycin receptor recombination region riboswitches ribozyme rld1 RNA interference role scientific scientists sequence signal siRNA Skp2 species stem cells strains structure Supplementary Fig surface target temperature transfected tubulin tumour University wild-type yeast