Melatonin: Present and Future
Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This important book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
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Melatonin Relationship with Cell Death
A Wide Range of Melatonin Actions in the Immune System
Melatonin on Hepatobiliary and Pancreatic Diseases
Effects of Melatonin on Cardiovascular System
Melatonin as a Radioprotective Agent
Melatonin Aging and Health
Melatonin and the Cytoprotective Role of Sleep
Melatonin and Sleep
Melatonin Reduces Molecular Damage and Physiological Dysfunction in Experimental Models of Neurodegeneration
Melatonin in Neuroprotection and Neurodevelopment
Neuroprotective Role of Melatonin Against Alzheimers Disease Huntingtons Disease and other Cerebral Disorders
acid actions of melatonin activity Acuña-Castroviejo administration of melatonin aging Alzheimer's disease amyloid antioxidant antioxidant enzymes apoptosis benzodiazepine Biochem Biol bone cancer cell death cellular circadian rhythm Clin cycle cytokines decrease disorders doses effect of melatonin Endocrinol endogenous enzymes Escames excitotoxicity factor free radicals function gene glutathione hormone human immune system increase indoleamine induced inhibition injury insomnia intracellular involved ischemia kinase Lett lipid peroxidation liver lymphocytes mechanisms mediated melatonin administration melatonin levels Melatonin prevents Melatonin protects melatonin receptors Melatonin reduces melatonin secretion melatonin treatment membrane metabolism mice mitochondrial modulation molecular molecule Montilla MPTP neurodegenerative neuronal neuroprotective Neurosci nitric oxide nocturnal NREM oxidative damage oxidative stress oxygen pathways patients Pharmacol Physiol physiological pineal gland Pineal Res pinealectomy Poeggeler production properties of melatonin Protective effect protein rats reactive redox regulation Reiter RJ response role of melatonin sleep-wake studies superoxide synthase synthesis tissues toxicity vitro vivo wakefulness