Melatonin: Present and Future

Front Cover
Nova Publishers, 2007 - Medical - 371 pages
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Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. The synthesis and release of melatonin are stimulated by darkness and suppressed by light, suggesting the involvement of melatonin in circadian rhythm and regulation of diverse body functions. Levels of melatonin start to increase prior to bedtime. Synthetic melatonin supplements have been used for a variety of medical conditions, most notably for disorders related to sleep. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This important book presents a full spectrum of research on melatonin and is destined to become an essential reference for anyone interested in melatonin.
 

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Contents

Melatonin Mitochondria and Neuroprotection
1
Melatonin Relationship with Cell Death
35
A Wide Range of Melatonin Actions in the Immune System
59
Melatonin on Hepatobiliary and Pancreatic Diseases
89
Effects of Melatonin on Cardiovascular System
109
Melatonin as a Radioprotective Agent
127
Melatonin Aging and Health
143
Melatonin and the Cytoprotective Role of Sleep
175
Melatonin and Sleep
217
Melatonin Reduces Molecular Damage and Physiological Dysfunction in Experimental Models of Neurodegeneration
261
Melatonin in Neuroprotection and Neurodevelopment
299
Neuroprotective Role of Melatonin Against Alzheimers Disease Huntingtons Disease and other Cerebral Disorders
315
Index
349
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