Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications

Front Cover
John Wiley & Sons, Jul 31, 2009 - Science - 312 pages
Discover the link between the latest chemical biology approaches and novel drug therapies!

Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications takes readers beyond the use of chemical biology in basic research, providing a highly relevant look at techniques that can address the challenges of biology and drug design and development.

This indispensable bench companion features up-to-date coverage of advances in chemistry and assesses their impact on developing new therapeutics, making it ideal for chemical biologists and medicinal chemists who are developing small molecule drugs to target proteins and treat diseases. In addition, the book examines the full range of complex biological systems and their interrelationship with chemistry, from the interaction of biological response modifiers with proteins to the chemical biology of cell surface oligosaccharides.

Distinguished by an overview of chemical biology that is reinforced and clarified by detailed examples and descriptions of techniques, Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications:

  • Introduces key technologies and methods of chemical biology designed to detect the interactions of small molecules and proteins
  • Facilitates the discovery of small molecules that bind to proteins and describes the molecules' application in the investigation of biological processes
  • Presents timely coverage of the development of fluorescent probes for small molecules, as well as the generation of small molecule ligands and inhibitors
  • Reviews important techniques such as chemical genomics, target profiling, immobilization technology, detection methods, chemical inhibition, and structure-based targeting
  • Offers a compelling synopsis of data that underscores the recent progress made in the area of targeting proteins by small molecules
 

What people are saying - Write a review

We haven't found any reviews in the usual places.

Contents

1 Chemical Biology Based on Small MoleculeProtein Interaction
1
2 Target Profiling of Small Molecules
11
3 Novel Applications of Affinity Beads
39
4 Recent Developments and Advances in Chemical Arrays
57
5 Use of the Phage Display Technique to Identify the Target Protein
81
6 Development of Fluorescent Probes for Small Molecules
91
7 Development of SmallMolecule Ligands and Inhibitors
115
8 Interaction of a Biological Response Modifier with Proteins
149
9 Chemical Biology of Cell Motility Inhibitors
169
10 Chemical Biology of Cell Surface Oligosaccharides
189
11 Chemical Genomics Based on Yeast Genetics
223
12 Data on Small Molecules and Their Target Proteins
239
Copyright

Other editions - View all

Common terms and phrases

About the author (2009)

Hiroyuki Osada is the Director and Chief Scientist in the Chemical Biology Department of RIKEN Advanced Science Institute and he is heading the RIKEN Natural Products Depository, RIKEN NPDepo. He is a former research fellow at the National Cancer Institute of the NIH. Dr. Osada is on the advisory boards of ACS Chemical Biology and Chemistry: An Asian Journal. In addition, he is an editorial member of four other journals, including Journal of Antibiotics and Journal of Microbiology and Biotechnology.

Bibliographic information