February 23rd.-A thin layer of the undiluted paste was applied on cotton to the surface of the ulcer.

24th. The ulcer is covered with a black, almost horny scale. This was scored to-day. The whole mass seems broader, and is redder below.

25th.-Redness less; the pains which she experienced before the treatment began have not increased, but after each dressing she has decided "darting" pain, which continues into the night.

26th. The mass has diminished in depth, whilst there has been no alteration in the lower part of the tumour. The shrinking must, therefore, arise from the action of the remedy on the upper part of the tumour. The pain from the application is less; that which she experienced before the treatment began is unaltered.

March 2nd. The change is most remarkable. The upper part of the tumour is much sunken, and more of the upper lid appeared. The skin covering the front of the tumour has been gradually destroyed, and the ulcer, which at first was horizontal, is now nearly vertical. The depth of the incisions is not more than half an inch, but that measurement does not nearly represent the depth to which the tumour has been destroyed. The undestroyed skin over the tumour is assuming a very healthy appearance, and is becoming freed from its connection with the diseased growth.

7th.-Half an inch more skin has sloughed as the tumour beneath it yielded to the action of the remedy. She feels during the dressing as if something were being put into her eye. The conjunctiva is inflamed. A nitrate of silver lotion was ordered.

11th. The dressings were discontinued. The stramonium ointment was applied over and around the eschar.

14th. Some redness has come on upon the nose, and extended to the inner canthus of the right eye, which is œdematous. A gland over the left masseter became enlarged and tender, and she complained of great pain, as it were in the malar bone. The redness continued several days, without spreading as erysipelas does, and was gone after a brisk purging, by the 25th.

27th. The eschar loosened itself all round, rose above the surrounding surface, and fell out this day. A healthy granulating surface was exposed, reaching to the lachrymal bone; but so remarkable had been the contraction of the healthy parts before the fall of the tumour, that the area of the healing sore was not equal to more than half that of the tumour. The inner half of the lower lid and the palpebral conjunctiva belonging to it were removed in the tumour.

April 19th.-Except a part at the inner canthus not more than half an inch square, where the granulations are healthy and on a level with the adjacent skin, the whole surface has cicatrized. When made to close her nostrils and blow her nose, no air has been observed at any time to escape through the nasal duct, at the wound. In the process of healing, owing to the contraction of the newly formed skin on the side of the nose, the left ala nasi has been slightly drawn upwards. May 1st.-Patient discharged well.

THE END.

LONDON:

SAVILL AND EDWARDS, PRINTERS,

CHANDOS STREET.

"It would be unjust to conclude this notice without saying a few words in favour of Mr. Churchill, from whom the profession is receiving, it may be truly said, the most beautiful series of Illustrated Medical Works which has ever been published."-Lancet. "All the publications of Mr. Churchill are prepared with so much taste and neatness, that it is superfluous to speak of them in terms of commendation." - Edinburgh Medical and Surgical Journal.

"No one is more distinguished for the elegance and recherché style of his publications than Mr. Churchill."-Provincial Medical Journal.

"Mr. Churchill's publications are very handsomely got up: the engravings are remarkably well executed."-Dublin Medical Press.

"The typography, illustrations, and getting up are, in all Mr. Churchill's publications, most beautiful."-Monthly Journal of Medical Science.

"Mr. Churchill's illustrated works are among the best that emanate from the Medical Press."-Medical Times.

"We have before called the attention of both students and practitioners to the great advantage which Mr. Churchill has conferred on the profession, in the issue, at such a moderate cost, of works so highly creditable in point of artistic execution and scientific merit."-Dublin Quarterly Journal.

များ

MR. CHURCHILL is the Publisher of the following Periodicals, offering to Authors a wide extent of Literary Announcement, and a Medium of Advertisement, addressed to all Classes of the Profession. COMMUNICATIONS, BOOKS for REVIEW, addressed to the respective Editors, are received and duly forwarded by Mr. Churchill.

THE BRITISH AND FOREIGN MEDICO-CHIRURGICAL REVIEW;

OR,

QUARTERLY JOURNAL OF PRACTICAL MEDICINE.

Price Six Shillings. Nos. I. to XXXVIII.

THE QUARTERLY JOURNAL OF MICROSCOPICAL SCIENCE.

Edited by EDWIN LANKESTER, M.D., F.R.S., F.L.S., and GEORGE BUSK, F.R.C.S.E., F.R.S., F.L.S. Price 4s. Nos. I. to XIX.

THE MEDICAL TIMES AND GAZETTE.
Published Weekly, price Sevenpence, or Stamped, Eightpence.

Annual Subscription, £1.10s., or Stamped, £1. 14s. 8d., and regularly forwarded to all parts of the Kingdom.

The MEDICAL TIMES AND GAZETTE is favoured with an amount of Literary and Scientific support which enables it to reflect fully the progress of Medical Science, and insure for it a character, an influence, and a circulation possessed at the present time by no Medical Periodical.

THE

HALF-YEARLY

MEDICAL

ABSTRACT OF THE
SCIENCES.

Being a Digest of the Contents of the principal British and Continental Medical Works; together with a Critical Report of the Progress of Medicine and the Collateral Sciences. Edited by W. H. RANKING, M.D., Cantab., and C. B. RADCLIFFE, M.D., Lond. Post 8vo. cloth, 6s. 6d. Vols. I. to XXIV.

THE JOURNAL OF PSYCHOLOGICAL MEDICINE

AND MENTAL PATHOLOGY.

Being a Quarterly Review of Medical Jurisprudence and Insanity. Edited by FORBES WINSLOW, M.D. Price 3s. 6d. Nos. I. to VI. New Series.

THE

PHARMACEUTICAL

JOURNAL.

EDITED BY JACOB BELL, F.L.S., M.R.I.

Published Monthly, price One Shilling.

*** Vols. I. to XV., bound in cloth, price 12s. 6d. each.

THE DUBLIN MEDICAL PRESS.

Published Weekly, Stamped, price Sixpence, free to any part of the Empire.

THE LONDON AND PROVINCIAL MEDICAL DIRECTORY. Published Annually. 12mo. cloth, 8s. 6d.