Nature, Volume 427Sir Norman Lockyer Macmillan Journals Limited, 2004 - Electronic journals |
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Page 84
... Kinase contains 1,200 known kinase substrates peptides in duplicate on a chip . For drug development and signal transduction research , PepChip Kinase opens up a range of new applications in the areas of substrate optimisation , kinase ...
... Kinase contains 1,200 known kinase substrates peptides in duplicate on a chip . For drug development and signal transduction research , PepChip Kinase opens up a range of new applications in the areas of substrate optimisation , kinase ...
Page 257
... kinase cascade to induce oncogenic transformation * , we examined the potential contribution of IMP to Ras signalling . We expressed IMP together with the oncogenic Raf variant RafBXB5 , or the constitutively active MEK variant MEKR4F ...
... kinase cascade to induce oncogenic transformation * , we examined the potential contribution of IMP to Ras signalling . We expressed IMP together with the oncogenic Raf variant RafBXB5 , or the constitutively active MEK variant MEKR4F ...
Page 259
... kinase cascade is Ras sensitive . Therefore , Ras is probably coupled to the MAP kinase cascade through dual effector interactions that mediate activation of Raf kinase together with derepression of Raf - MEK complex formation . We ...
... kinase cascade is Ras sensitive . Therefore , Ras is probably coupled to the MAP kinase cascade through dual effector interactions that mediate activation of Raf kinase together with derepression of Raf - MEK complex formation . We ...
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