Nature, Volume 448Sir Norman Lockyer Macmillan Journals Limited, 2007 - Electronic journals |
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Page 207
... camptothecin class of chemother- apeutics2,3,11 . The camptothecin analogues topotecan and irinotecan have significant activity against adult and paediatric solid tumours , and have gained US Food and Drug Administration approval for ...
... camptothecin class of chemother- apeutics2,3,11 . The camptothecin analogues topotecan and irinotecan have significant activity against adult and paediatric solid tumours , and have gained US Food and Drug Administration approval for ...
Page 210
... camptothecin ( Fig . 3b , left ) or no drug ( Fig . 3b , right ) . Arresting cells in G1 phase restricted the analysis to transcription - induced DNA supercoiling , and camptothecin was used to avoid drug transporter efflux of topotecan ...
... camptothecin ( Fig . 3b , left ) or no drug ( Fig . 3b , right ) . Arresting cells in G1 phase restricted the analysis to transcription - induced DNA supercoiling , and camptothecin was used to avoid drug transporter efflux of topotecan ...
Page 211
... camptothecin or 0.25 % DMSO ( v / v ) ( no drug ) , or washed by filtra- tion and released into S phase with or without camptothecin . Asynchronous cultures , incubated with 1 or 5 μM camptothecin for 15 min at 30 ° C , were treated as ...
... camptothecin or 0.25 % DMSO ( v / v ) ( no drug ) , or washed by filtra- tion and released into S phase with or without camptothecin . Asynchronous cultures , incubated with 1 or 5 μM camptothecin for 15 min at 30 ° C , were treated as ...
Contents
Crinan St London N19XW | 4 |
How T cells recognize sugars | 27 |
68 | 43 |
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activity adhesive analysis applications beam binding Biol biology boson brain Ca2+ calmodulin CD1d CDNF CERN channel clones collisions complex density detected detector e-mail ecosystem effects electron energy epiblast EpiSCs experiments expression factors function gene genetic genome Hadron Higgs Higgs boson human imaging Institute interactions iPS cells Laboratory Large Hadron Collider levels magnetic measurements mechanism methylation mice mimics molecular mouse ES cells mutant Nanog Nanog iPS nature publishing group naturejobs neurons observed Oct4 paper at www.nature.com/nature particles peptide photon Phys physics plants pluripotent position potential protein quantum quark-gluon plasma quarks Rab8 receptor RNAi RNAP scientific scientists sequence signalling silicon siRNA Sox2 species standard model stem cells structure substrate supercoils Supplementary Fig Supplementary Information Supplementary Table surface target temperature theory tion topotecan transcription transform fault transgenic TRPM8 University wild-type