Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent AdvancesFrank I. Marcus, Andrea Nava, Gaetano Thiene This book covers all the recent research highlights of arrhythmogenic right ventr- ular cardiomyopathy/dysplasia (ARVC/D), a recently discovered heart muscle d- ease which is a major threat to the life of affected young people. It summarizes ne- ly 25 years of investigation on the etiology, genetics, pathology, clinical features, - agnosis, and treatment of ARVC/D. In particular, a 5-year research program supported by grants from both the European Community and the National Heart, Lung and Blood Institutes has contributed to the discovery of seven disease-causing genes, thus opening new avenues for the early identification of affected patients and prevention of sudden death. A Workshop was held in Venice, Italy, October 3, 2005, as part of the Venice - rhythmia Meeting, where the European and American investigators presented and discussed several major achievements which are now reported in this book.As a - sult of these coordinated efforts, great advances have been made in the recognition and understanding of the disease, which are summarized in this book. |
Contents
CHAPTER | 11 |
RECESSIVE FORMS | 15 |
CHAPTER | 17 |
AUTOPSY AND ENDOMYOCARDIAL BIOPSYFINDINGS | 29 |
CELL ADHESION PATHOLOGY | 45 |
TRANSGENIC ANIMAL MODELS | 61 |
POSSIBLE CAUSATIVE OR CONTRIBUTING ROLE OF VIRUSES | 81 |
210 | |
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Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent Advances Frank I. Marcus,Andrea Nava,Gaetano Thiene No preview available - 2014 |
Common terms and phrases
ablation abnormalities activity affected analysis animal areas arrhyth arrhythmogenic right ventricular assessment associated athletes Basso cardiac catheter cause cell characterized Circulation clinical Coll Cardiol considered consistent Corrado criteria desmoplakin desmosomal detected diagnosis dilated diomyopathy disease drug dysfunction electrical et al evaluation evidence expression fatty fibro-fatty findings follow-up gene genetic heart heart failure human identified idiopathic imaging increased induced infiltration involvement Italy junctions leads left ventricular major mapping mean mechanical models morphology mutations myocardial myocardium myocytes Nava Naxos normal observed outflow tract patients with ARVC/D plakoglobin present progression proteins regional replacement reported right ven right ventricle right ventricular cardiomyopathy right ventricular dysplasia risk RVOT severe showed signal structural subjects sudden death suggesting Table Task Force therapy Thiene G tients tion tissue tricular ventricular arrhythmias ventricular tachycardia wall young
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