Pharmacological Potential of Selected Natural Compounds in the Control of Parasitic Diseases
Springer Science & Business Media, Dec 13, 2012 - Medical - 125 pages
The natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. Additionally, the advantages of combined therapy using antiparasitic drugs and natural compounds with selected specific activity are reviewed and explained in the context of host pathology and immunosuppression induced by the parasites. The conclusions of this new book give suggestions for further non-empirical drug development and discuss perspectives of alternative approaches to therapy of parasitic diseases.
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Health Impact and Control
3 Natural Compounds Exerting Anthelmintic andor HostProtecting Effects During Parasitic Infections
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acid adult worms alkaloids amastigotes animals anthelmintic anthelmintic activity anthelmintic effect antifilarial activity antileishmanial activity antimalarial Antimicrob Agents Chemother antioxidant antiparasitic antiprotozoal artemether Artemisia artemisinin artesunate avermectins bioactive biochemical cells cestodes components concentration condensed tannins cruzi curcumin cytotoxicity diseases donovani dose drug resistance efficacy enzymes essential oils evaluated Exp Parasitol experimental falciparum Fasciola flatworms flavonoids gastrointestinal nematodes genistein glycosides Haemonchus contortus helminths host human IC50 values immune immunomodulatory inhibition inhibitors isolated Keiser larvae Leishmania lg/ml liver macrophages malaria medicinal membrane metabolism methanol mg/kg mg/ml mice mode of action molecules natural compounds natural products nematocidal nematodes oxidative parasite Parasitol Res phenolic phytochemicals plant extracts Plasmodium potential praziquantel promastigotes protein protozoan reduction ruminants saponins Schistosoma mansoni schistosomiasis secondary metabolites sesquiterpene lactones sheep silymarin species stages tannins target tegument therapy toxicity treatment trematodes trypanocidal Trypanosoma Utzinger Velebny vitro Xiao SH