The Autoimmune Diseases

Front Cover
Ian R. Mackay, Noel R Rose
Elsevier, May 15, 2006 - Medical - 1160 pages
Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels.

New to This Edition:
* Tissue-specific interventions to arrest or "cure" autoimmune disease
* Bone marrow eradication and replacement
* Both basic science and clinical medicine is covered
* Boxed points to emphasize key features of each chapter
 

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Contents

Section II Autoimmune Diseases Multisystem Diseases
349
Section III Diagnosis Prevention and Therapy
1009
Section IV Epilogue
1083

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About the author (2006)

In the 1950s and 1960s Professor Mackay led the field of research into autoimmune diseases, coining the term ‘autoimmunity’.
In 1963, he and Sir Macfarlane Burnet published a definitive monograph on the subject, firmly placing autoimmunity on the research map. Professor Mackay defined major autoimmune diseases of the liver and devised a life-saving protocol for autoimmune hepatitis that remains standard today. He also advanced knowledge on many other expressions of autoimmunity.

Noel Rose was born in Stamford, Connecticut. He attended Yale University for his undergraduate education followed by the University of Pennsylvania for a Ph.D. and State University of New York at Buffalo for an MD. He was a member of the faculty of the State University of New York at Buffalo School of Medicine for a period of 20 years, rising through the ranks to become a professor of Microbiology and Medicine, Director of Clinical Laboratories and Director of the Center for Immunology. He then spent ten years at Wayne State University School of Medicine where he chaired the Department of Immunology and Microbiology. In 1981, he joined the faculty of Johns Hopkins University as chairman of the Department of Immunology and Infectious Diseases. He presently holds professorial appointments in the Departments of Pathology, Molecular Microbiology and Immunology, Medicine and Environmental Health Sciences at The Johns Hopkins University and directs the Center for Autoimmune Disease Research. Dr. Rose’s original investigations on the autoimmune basis of thyroid disease in 1956 opened the present era of research on autoimmunity. He has since investigated many areas of autoimmunity and related issues in clinical and basic immunology. Dr. Rose is the author or co-author of over 800 scientific papers and editor or co-editor of 24 books. He has received numerous honors, including two honorary doctoral degrees, election to fellowship in national or international societies, service in national and international organizations and editorial boards of leading journals.

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