Controlled Drug Delivery: Designing Technologies for the FutureControlled Drug Delivery examines the current state of drug deliverytechnologies and discusses the future directions of drug delivery development.Topics include advances for increasing the uptake of orally delivered drugs,modulating blood levels for better drug safety/efficacy profiles, targetingdrugs and genes for cellular and intracellular delivery, improving the deliveryof poorly soluble drugs and recent advances in polymer-based drug deliverytechnologies. |
Contents
ControlledRelease Oral Delivery Systems | 14 |
A Fiction? Polymers | 25 |
Prodrug Strategies to Improve the Oral Absorption of Peptides | 36 |
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absorption acid activity addition agents American Chemical Society applications approach aqueous blood buffer carriers cationized cells challenge Chemical clinical compared complex compounds concentration conjugates containing controlled cytoplasm decreased dependent determined dissolution dosage forms drug delivery drug release effect enhanced enzymes factors Figure fluorescence formulations gene glucose growth half-life higher human hydrophobic improved incorporated increased indicated interaction intestinal LCST lipid lipoproteins liposomes lower matrix measured mechanism membrane method micelles microspheres molecular weight molecules nanoparticles NASI observed obtained oral peptide permeability Pharm phase plasma polymer polymeric potential prepared present prodrugs profiles properties protein ratio rats reference release response sample showed shown solubility solution specific stability structure studies surface Table tablets targeting temperature therapeutic tissue transition transport tumor values vitro vivo