Natural Products: Drug Discovery and Therapeutic MedicineLixin Zhang, Arnold L. Demain A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious. |
Contents
Integrated Approaches for Discovering Novel Drugs | 33 |
Manipulating Microbial Metabolites for Drug Discovery | 77 |
Improving Drug Discovery From Microorganisms | 95 |
The Discovery of Anticancer Drugs From Natural Sources | 129 |
Novel Antitumor Agents | 169 |
Terpenoids As Therapeutic Drugs and Pharmaceutical Agents | 197 |
Challenges and Opportunities in the Chinese Herbal Drug Industry | 229 |
From Bedside to Bench | 251 |
Other editions - View all
Natural Products: Drug Discovery and Therapeutic Medicine Lixin Zhang,Arnold L. Demain No preview available - 2007 |
Natural Products: Drug Discovery and Therapeutic Medicine Lixin Zhang,Arnold L. Demain No preview available - 2010 |
Natural Products: Drug Discovery and Therapeutic Medicine Lixin Zhang,Arnold L. Demain No preview available - 2005 |
Common terms and phrases
acid actinomycetes acute promyelocytic leukemia alkaloids analogs antibiotics anticancer antifungal apoptosis Appl Environ Microbiol arsenic trioxide artemisinin assays bacteria bioactive biodiversity Biol biological activities biosynthesis Biotechnol cell lines Chem chemical diversity chemistry Chen Chinese clinical trials clones coli combinatorial compounds culture Curr cytotoxic derivatives disease dolastatin drug discovery effects eleutherobin encoded endophytes engineering environmental DNA environmental libraries enzymes epothilone erythromycin expression extracts fermentation fungal fungi gene clusters genetic genome herbal drug heterologous high-throughput host HPLC improved industry inhibition inhibitors isolated JAm Chem Soc Lett medicine metabolic microbial microorganisms microtubules molecular molecules monoterpenes Nat Prod natural products natural-product novel organisms paclitaxel pathways patients pharmaceutical phase plant polyketide synthases potential protein recombinant result screening secondary metabolites sequence shuffling species sponge strains Streptomyces Structure studies synthetic target taxol terpenoids therapeutic tion total synthesis toxic treatment tubulin tumor vinblastine vitro vivo Zhang