Natural Products: Drug Discovery and Therapeutic Medicine

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Lixin Zhang, Arnold L. Demain
Springer Science & Business Media, Nov 17, 2007 - Medical - 386 pages
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A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.
 

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Contents

Integrated Approaches for Discovering Novel Drugs
33
Manipulating Microbial Metabolites for Drug Discovery
77
Improving Drug Discovery From Microorganisms
95
The Discovery of Anticancer Drugs From Natural Sources
129
Novel Antitumor Agents
169
Terpenoids As Therapeutic Drugs and Pharmaceutical Agents
197
Challenges and Opportunities in the Chinese Herbal Drug Industry
229
From Bedside to Bench
251
New Methods to Access Microbial Diversity
275
Accessing the Genomes of Uncultivated Microbes
295
New NaturalProduct Diversity From Marine Actinomycetes
315
Novel Natural Products From Rainforest Endophytes
329
Biological Economic Ecological and Legal Aspects
353
INDEX
371
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