Drugs and Human Lactation: A Guide to the Content and Consequences of Drugs, Micronutrients, Radiopharmaceuticals, and Environmental and Occupational Chemicals in Human Milk
Elsevier, 1988 - Medical - 589 pages
Co-Editors and Members of the WHO Working Group: M.N.G. Dukes, I. Matheson, L. Notarianni, M.L'E. Orme, A. Rane, D. Reinhardt, P. Soderman and J.T. Wilson This book is not the first attempt to provide an overview of the excretion and effects of drugs in human milk, but it is by far the most thorough and extensive ever undertaken. # all original evidence re-examined # a stimulus to new research # tips to avoid risks and false alarms A WHO team has re-examined all the original scientific evidence of drug excretion in breast milk and the effects of drugs on the lactation process and the ultimate effects of these processes on the child and mother. The result is a complete overview of what is known and proven, with clear pointers as to those matters which require further study or when evidence is completely lacking. To those involved in the field the material in this book is above all reassuring. The risks and uncertainties which exist have been defined in such a way that they can be avoided and the false alarms have been silenced.
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List of Contributors
Determinants of drug excretion in breast milk
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Absolute dose absorbed acid administering amount appears ASSESSMENT AND RECOMMENDATIONS ATC CODE average basis blood breast milk breast-fed breast-feeding calculated calculation(s Clin DATA Passage dietary distribution DOSE IN MILK dose to infant Dose x Frequency drug effects EVALUATION OF DATA excretion explanation feed Frequency x Duration given gives human milk infant mg/kg/d infant of administering infant would ingest intake Lactation stage Milk levels maternal dose Maximum observed milk metabolites mg/l milk and plasma milk concentration milk is small Milk to plasma months mother nursing observed milk concen oral passes into milk patients Pediatr Pharmacol plasma half-life plasma proteins pregnancy quantity of drug quoted ratio Maximum observed received REFERENCES regarded RELATIVE DOSE reported as follows risk Route samples serum single dose steady suckling infant supplementation Table taken tion Treatment conditions Ref urine values vitamin volume weeks women