Drugs and Human Lactation: A Comprehensive Guide to the Content and Consequences of Drugs, Micronutrients, Radiopharmaceuticals and Environmental and Occupational Chemicals in Human Milk

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Elsevier, Dec 3, 1996 - Medical - 712 pages
Now in its second edition, Drugs and Human Lactation is a comprehensive guide to the content and consequences of xenobiotics and micronutrients in human milk, and remains by far the most thorough and extensive work available on this subject. The excellent methodology used for the compilation of the 1st edition has been retained.

It begins with an outline of the processes by which substances enter milk during its formation, the effects of drugs on the milk production process, the main determinants of drug excretion into milk and their disposition in the child. There follows an analysis of current data on 234 individual drugs, describing the extent of their passage into human milk, and assessing the risk to the suckling infant. Vitamins and essential trace elements, and radiopharmaceuticals are similarly reviewed. Also included is an account of the factors that influence the passage of environmental and occupational chemicals into milk. The result is a complete overview of what is known and proven, with clear pointers to matters which require further study, and brings the various subject areas up to date. Risks, uncertainties and false alarms which exist have been defined in such a way that they can be avoided.

Once again, Drugs and Human Lactation provides a comprehensive guide to the content and consequences of substances in milk. The volume will provide a rational basis for making therapeutic decisions in women who seek to breast-feed.

Reproductive Immunology on the first edition: ...a superbly written compendium of reliable information and sensible conclusions and recommendations.

 

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Contents

Chapter 1 Is breast best? Milk and formula feeds
1
Chapter 2 Effects of drugs on milk secretion and composition
15
Chapter 3 Determinants of drug transfer into human milk
47
Chapter 4 Determinants of drug disposition in infants
59
Chapter 5 Use of the monographs on drugs
67
Chapter 6 Monographs on individual drugs
75
Chapter 7 Vitamins minerals and essential trace elements
533
Chapter 8 Radiopharmaceuticals
609
Chapter 9 Environmental and occupational chemicals
679
Index
707
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