Autophagy and Cancer
Springer Science & Business Media, Mar 30, 2013 - Medical - 261 pages
With the explosion of information on autophagy in cancer, this is an opportune time to speed the efforts to translate our current knowledge about autophagy regulation into better understanding of its role in cancer. This book will cover the latest advances in this area from the basics, such as the molecular machinery for autophagy induction and regulation, up to the current areas of interest such as modulation of autophagy and drug discovery for cancer prevention and treatment. The text will include an explanation on how autophagy can function in both oncogenesis and tumor suppression and a description of its function in tumor development and tumor suppression through its roles in cell survival, cell death, cell growth as well as its influences on inflammation, immunity, DNA damage, oxidative stress, tumor microenvironment, etc. The remaining chapters will cover topics on autophagy and cancer therapy. These pages will serve as a description on how the pro-survival function of autophagy may help cancer cells resist chemotherapy and radiation treatment as well as how the pro-death functions of autophagy may enhance cell death in response to cancer therapy, and how to target autophagy for cancer prevention and therapy − what to target and how to target it.
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Chapter 2 The Core Molecular Machinery of Autophagosome Formation
Chapter 3 The Origin of Autophagosomes The Beginning of an End
Chapter 4 Signal Transduction Regulation of Autophagy
Chapter 5 Role of Autophagy in Tumorigenesis
Chapter 6 Selective Autophagy and Cancer
Chapter 7 Oncogenes and Tumor Suppressor Genes in Autophagy
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Acad Sci USA amino acids AMPK apoptosis Atg proteins Atg5 Atg7 Atg8 Atg9 Atgl autoph autophagosomal membranes autophagosome autophagosome formation autophagy autophagy gene autophagy in cancer autophagy induction autophagy inhibitors autophagy pathway Beclin Bif-l binding Biol Chem cancer cells caspase caspase-8 cell death cell survival cellular chloroquine conjugation conjugation system cytokines cytoplasmic cytosolic degradation endoplasmic reticulum endosomes ﬁrst function identiﬁed immune induce autophagy induction of autophagy inﬂammation interaction intracellular knockout Komatsu Levine lipid liver lysosomes macroautophagy mammalian cells mechanism mediated mice mitochondria mitophagy Mizushima Mol Biol Cell Mol Cell molecular mTOR mTORCl mutant Nat Cell Biol Natl Acad Sci negatively regulates NF-KB Nrf2 nutrient Ohsumi Oncogene organelles phagophore phosphorylation PI3K Proc Natl Acad promotes proteasome PtdIns3K rapamycin receptor regulate autophagy regulation of autophagy response role of autophagy Saccharomyces cerevisiae signaling speciﬁc starvation stress suppression target tion tumor cells tumor suppressor tumorigenesis ubiquitin ULK1 ULK1 complex UVRAG vacuole vesicles yeast