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activity alleles amino acid analysis antigen binding Biochem Biol breeding cells chromatin chromo chromosome clones Coll complex cone correlated culture cytoplasmic density detected determined differentiation diploid disease DNA synthesis E.coli effect enzyme Escherichia coli factors fraction frequency function gene genetic genome genotype growth histone Hosp hybrid incorporation increase incubation indicate induced infection inhibition Inst irradiation isolated karyotype labeled liver locus lymphocytes membrane ment metabolism metaphase mice Microbiol mitosis mitotic mol wt molecules mouse mRNA mutagenic mutants Natl normal nuclear nuclei nucleotide observed parents patients pattern phage phenotype Plant plasmid population present production progeny protein synthesis replication resistance ribosomes RNA polymerase rRNA selection sequence serum showed specific strs structure studied subunits suggested syndrome temp tested tion tissue treatment tRNA Univ USSR viral virus vitro vivo wild-type yield