Joslin's Diabetes Mellitus

abnormalities Acta activity adipocytes alloxan alterations amino acids animals antibodies antigens associated atherosclerosis autoimmune basement membrane beta cell betes betic Biochem Biol blood glucose capillary carbohydrate Chem cholesterol Clin decreased diabetes mellitus diabetic nephropathy diabetic patients diabetic rats Diabetologia diagnosis disease effect of insulin Endocrinol Engl enzyme factors fasting genetic glomerular glomerular basement membrane glucagon glucose tolerance glycosylation growth hormone hepatic human hyperglycemia IDDM incidence rates increased infection insulin action insulin binding insulin levels insulin receptor insulin release insulin resistance insulin secretion insulin-dependent diabetes insulitis intracellular Invest islet cell islets of Langerhans Joslin Clinic Lancet lesions lipid lipoprotein liver Metab metabolism mice mortality mouse muscle nerve neuropathy NIDDM nondiabetic normal obese observed occur onset pancreatic islets pathogenesis plasma platelet polypeptide population prevalence rates Proc protein renal response retinopathy role serum somatostatin stimulation streptozotocin studies sulin syndrome synthesis tion tissue Type vascular