The Path to the Double Helix: The Discovery of DNA
One of the most dramatic events in the history of science was the discovery in 1953 by James Watson and Francis Crick of the molecular structure of DNA. In this lively, perceptive and scholarly study, a noted historian of science provides the first full in-depth account of how this scientific milestone was reached. Combining scientific and historial approaches, Professor Olby (University of Pittsburgh) vividly captures the excitement of conceptualization and the evolution of ideas that led to the discovery of the genetic "secret of life." The story unfolds along several major lines: long-chain macromolecules; nucleic acids; bacterial transformations; the intellectual evolution of physicists, chemists and biologists (including Watson and Crick); and the combination of scientific disciplines that unlocked the structural secrets of DNA. Abundantly illustrated, this superb retelling of one of the greatest scientific detective stories offers stimulating and thought-provoking reading. Now available for the first time in paperback, it belongs in the library of anyone interested in how brilliant science and dogged determination led to one of the most crucial discoveries of the 20th century. -- from back cover.
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adenine amino acids Astbury Astbury’s atoms Avery Avery’s bacterial bases Beadle Bernal birefringence Boivin Bragg Caltech Cambridge Caspersson cellulose cent Chargaff chemical chemist chemistry chromatin chromosomes colloidal conﬁguration Corey crystal crystalline crystallography cytosine Darlington deﬁnite Delbriick diagram diffraction discovery enzyme evidence Fankuchen ﬁbre ﬁeld ﬁnd ﬁrst Fourier Franklin Garrod gene genetic Gosling guanine helical Huggins hydrogen bonds inﬂuence Institute keratin King’s laboratory later Leeds Levene Luria McCarty metabolism Mirsky molecular biology molecular weight molecules Muller mutation nature nucleic acid nucleoprotein nucleotides organic pairing paper particles pattern Pauling Pauling’s peptide Perutz phage phosphate physicist physics picture pneumococcus polypeptide polypeptide chain possible problem protein purine pyrimidine reﬂections replication residues Rockefeller scientiﬁc sequence signiﬁcance speciﬁc sperm Staudinger structure substance suggested synthesis technique tetranucleotide theory transformation unit cell virus viruses Watson and Crick Wilkins wrote X-ray X-ray crystallography