Reflections on a Century of Malaria Biochemistry
Malaria is one of the most common infectious diseases and an enormous public health problem. Each year it causes disease in approximately 650 million people and kills between 1 and 3 million, most of them young children in Sub-Saharan Africa.
This book provides an overview of the research that has been done in malaria biochemistry in the quest to find a cure. It discusses how our understanding has helped us to develop better diagnostics and novel chemotherapies. Researchers will find having all of this information in one volume, annotated with personal reflections from a leader in the field, invaluable given the big push being made on various fronts to use the latest drug discovery tools to attack malaria and other developing country diseases.
* Reviews the past 100 years of malaria biochemistry research providing researchers with an overview of the investigations that have been undertaken in this field
Benefit: Allows researchers to see what progress has been made so that they can use this knowledge when trying to develop the latest drug discovery tools to attack malaria
* Chronicles both biochemical successes and failures
Benefit: Allows researchers to see what has and hasn't work which they can then apply in their own research
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New Permeability Pathways and Transport
Erythrocyte Surface Membrane Proteins
Erythrocyte Membrane Lipids
Invasion of Erythrocytes
Vitamins and AntiOxidant Defenses
The Road to the Plasmodium falciparum Genome
Pyrimidines and the Mitochondrion
The Road to Atovaquone
The Ring Road to the Apicoplast
Ribosomes and Ribosomal Ribonucleic Acid Synthesis
De Novo Synthesis of Pyrimidines and Folates
Salvage of Purines
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