Nature, Volume 452Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
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Page 182
... PKM2 , does not bind to phosphotyrosine peptides , we looked to the crystal structures of these isoforms for a potential phosphotyrosine - binding site on PKM2 . PKM1 and PKM2 are iden- tical proteins with the exception of a 56 - amino ...
... PKM2 , does not bind to phosphotyrosine peptides , we looked to the crystal structures of these isoforms for a potential phosphotyrosine - binding site on PKM2 . PKM1 and PKM2 are iden- tical proteins with the exception of a 56 - amino ...
Page 183
... PKM2 did not ffect phosphotyrosine peptide binding ( data not shown ) , mutation f lysine 433 - located within the unique region of PKM2 , which lies t the lip of the pocket - to glutamate abolished phosphotyrosine peptide binding ...
... PKM2 did not ffect phosphotyrosine peptide binding ( data not shown ) , mutation f lysine 433 - located within the unique region of PKM2 , which lies t the lip of the pocket - to glutamate abolished phosphotyrosine peptide binding ...
Page 185
... PKM2 in glycolysis under cell culture conditions , is important for its role in cell proliferation . Similar results ... PKM2 is important for cell 3 proliferation . cl pLHCX , cells with empty rescue vector and control shRNA ; kd ...
... PKM2 in glycolysis under cell culture conditions , is important for its role in cell proliferation . Similar results ... PKM2 is important for cell 3 proliferation . cl pLHCX , cells with empty rescue vector and control shRNA ; kd ...
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activity adenovirus analysis antibody applications assay atoms binding Biol Biology cancer candidate carbon CD8 T cells Center complex correlation CP violation crystals cytosine desalination detected differentiation DNA methylation drug effect electron energy environment enzyme experiments function gene expression genetic genome human images increase infection Institute interactions isotopic ketyl Lett levels magnetic mantle measured mechanism MEFs membrane methylation mGluR2 mice microRNA molecular molecules mouse mRNA mutant Nature Nature Publishing Group Naturejobs neuronal observed online version paper at www.nature.com/nature pars tuberalis peptide peridotites phosphotyrosine photon Phys PKM2 plant plasmasphere population position predicted production protein pS2 promoter pyruvate kinase quantum receptor region regulation response ribosome role samples SATB1 says Science scientists sequence shown shRNA signal specific structure studies Supplementary Fig Supplementary Table target tion transcription tumour University vivo wild-type