Nature, Volume 452Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
From inside the book
Results 1-3 of 78
Page 181
... binding proteins , we have made the observation that an enzyme involved in glycolysis , the human M2 ( fetal ) isoform of pyruvate kinase ( PKM2 ) , binds directly and selectively to tyrosine - phosphorylated peptides . We show that binding ...
... binding proteins , we have made the observation that an enzyme involved in glycolysis , the human M2 ( fetal ) isoform of pyruvate kinase ( PKM2 ) , binds directly and selectively to tyrosine - phosphorylated peptides . We show that binding ...
Page 182
... binding to the immobilized phosphotyrosine peptide library , it did not show selective binding to immobilized phosphoserine or phosphothreonine peptide libraries ( Supplementary Fig . 1 ) . pTyr binding is specific to pyruvate kinase ...
... binding to the immobilized phosphotyrosine peptide library , it did not show selective binding to immobilized phosphoserine or phosphothreonine peptide libraries ( Supplementary Fig . 1 ) . pTyr binding is specific to pyruvate kinase ...
Page 183
... binding pocket of PKM2 did not ffect phosphotyrosine peptide binding ( data not shown ) , mutation of lysine 433 - located within the unique region of PKM2 , which lies at the lip of the pocket - to glutamate abolished ...
... binding pocket of PKM2 did not ffect phosphotyrosine peptide binding ( data not shown ) , mutation of lysine 433 - located within the unique region of PKM2 , which lies at the lip of the pocket - to glutamate abolished ...
Other editions - View all
Common terms and phrases
activity adenovirus analysis antibody applications assay atoms binding Biol Biology cancer candidate carbon CD8 T cells Center complex correlation CP violation crystals cytosine desalination detected differentiation DNA methylation drug effect electron energy environment enzyme experiments function gene expression genetic genome human images increase infection Institute interactions isotopic ketyl Lett levels magnetic mantle measured mechanism MEFs membrane methylation mGluR2 mice microRNA midge molecular molecules mouse mRNA mutant Nature Nature Publishing Group Naturejobs neuronal observed online version paper at www.nature.com/nature pars tuberalis peptide peridotites phosphotyrosine photon Phys PKM2 plant plasmasphere population position predicted production protein pS2 promoter pyruvate kinase quantum receptor region regulation response ribosome role samples SATB1 says Science scientists sequence shown shRNA signal specific structure studies Supplementary Fig Supplementary Table target tion transcription tumour University vivo wild-type