Nature, Volume 452Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
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Page 181
... peptide library affinity matrix , and ' light ' lysates were flowed over a corres- ponding unphosphorylated peptide library affinity matrix . Bound proteins were eluted with sodium phenylphosphate , digested with trypsin , and the peptides ...
... peptide library affinity matrix , and ' light ' lysates were flowed over a corres- ponding unphosphorylated peptide library affinity matrix . Bound proteins were eluted with sodium phenylphosphate , digested with trypsin , and the peptides ...
Page 182
... peptide library Pyruvate kinase 50 100 150 200 250 300 Protein number d PY Y 75 c PY Y kDa 50 355 356 PKC - 8 350 Pyruvate kinase ( 58 kDa ) peptide library matrix . Notably , whereas pyruvate kinase exhibited selective binding to the ...
... peptide library Pyruvate kinase 50 100 150 200 250 300 Protein number d PY Y 75 c PY Y kDa 50 355 356 PKC - 8 350 Pyruvate kinase ( 58 kDa ) peptide library matrix . Notably , whereas pyruvate kinase exhibited selective binding to the ...
Page 183
... peptide binding ability still gets activated by FBP to a similar degree as the wild - type protein Supplementary Fig . 2 ) . These data suggest that phosphotyrosine peptides are binding to PKM2 near the FBP - binding pocket of the ...
... peptide binding ability still gets activated by FBP to a similar degree as the wild - type protein Supplementary Fig . 2 ) . These data suggest that phosphotyrosine peptides are binding to PKM2 near the FBP - binding pocket of the ...
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activity adenovirus analysis antibody applications assay atoms binding Biol Biology cancer candidate carbon CD8 T cells Center complex correlation CP violation crystals cytosine desalination detected differentiation DNA methylation drug effect electron energy environment enzyme experiments function gene expression genetic genome human images increase infection Institute interactions isotopic ketyl Lett levels magnetic mantle measured mechanism MEFs membrane methylation mGluR2 mice microRNA midge molecular molecules mouse mRNA mutant Nature Nature Publishing Group Naturejobs neuronal observed online version paper at www.nature.com/nature pars tuberalis peptide peridotites phosphotyrosine photon Phys PKM2 plant plasmasphere population position predicted production protein pS2 promoter pyruvate kinase quantum receptor region regulation response ribosome role samples SATB1 says Science scientists sequence shown shRNA signal specific structure studies Supplementary Fig Supplementary Table target tion transcription tumour University vivo wild-type