Nature, Volume 452Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
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Page 181
... phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose - 1,6 - bisphosphate , leading to inhibition of PKM2 enzymatic activity . We also provide evidence that this regulation of PKM2 by phosphotyrosine ...
... phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose - 1,6 - bisphosphate , leading to inhibition of PKM2 enzymatic activity . We also provide evidence that this regulation of PKM2 by phosphotyrosine ...
Page 182
... phosphotyrosine peptides . Given that PKM1 , the splice variant of PKM2 , does not bind to phosphotyrosine peptides , we looked to the crystal structures of these isoforms for a potential phosphotyrosine - binding site on PKM2 . PKM1 ...
... phosphotyrosine peptides . Given that PKM1 , the splice variant of PKM2 , does not bind to phosphotyrosine peptides , we looked to the crystal structures of these isoforms for a potential phosphotyrosine - binding site on PKM2 . PKM1 ...
Page 184
... phosphotyrosine levels was specific to the M isoform of pyruvate kinase and that it depended on the ability of PKM2 to bind to phosphotyrosine peptides , we constructed cell lines that express the M1 , M2 , L , or M2KE ( phosphotyrosine ...
... phosphotyrosine levels was specific to the M isoform of pyruvate kinase and that it depended on the ability of PKM2 to bind to phosphotyrosine peptides , we constructed cell lines that express the M1 , M2 , L , or M2KE ( phosphotyrosine ...
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activity adenovirus analysis antibody applications assay atoms binding Biol Biology cancer candidate carbon CD8 T cells Center complex correlation CP violation crystals cytosine desalination detected differentiation DNA methylation drug effect electron energy environment enzyme experiments function gene expression genetic genome human images increase infection Institute interactions isotopic ketyl Lett levels magnetic mantle measured mechanism MEFs membrane methylation mGluR2 mice microRNA midge molecular molecules mouse mRNA mutant Nature Nature Publishing Group Naturejobs neuronal observed online version paper at www.nature.com/nature pars tuberalis peptide peridotites phosphotyrosine photon Phys PKM2 plant plasmasphere population position predicted production protein pS2 promoter pyruvate kinase quantum receptor region regulation response ribosome role samples SATB1 says Science scientists sequence shown shRNA signal specific structure studies Supplementary Fig Supplementary Table target tion transcription tumour University vivo wild-type