Nature, Volume 452Sir Norman Lockyer Macmillan Journals Limited, 2008 - Electronic journals |
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Page 181
... pyruvate kinase ( PKM2 ) , binds directly and selectively to tyrosine - phosphorylated peptides . We show that binding of phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose - 1,6 - bisphosphate ...
... pyruvate kinase ( PKM2 ) , binds directly and selectively to tyrosine - phosphorylated peptides . We show that binding of phosphotyrosine peptides to PKM2 results in release of the allosteric activator fructose - 1,6 - bisphosphate ...
Page 182
... Pyruvate kinase 50 100 150 200 250 300 Protein number d PY Y 75 c PY Y kDa 50 355 356 PKC - 8 350 Pyruvate kinase ( 58 kDa ) peptide library matrix . Notably , whereas pyruvate kinase exhibited selective binding to the immobilized ...
... Pyruvate kinase 50 100 150 200 250 300 Protein number d PY Y 75 c PY Y kDa 50 355 356 PKC - 8 350 Pyruvate kinase ( 58 kDa ) peptide library matrix . Notably , whereas pyruvate kinase exhibited selective binding to the immobilized ...
Page 184
... pyruvate kinases . However , to confirm that the decrease in pyruvate kinase activity on increasing phosphotyrosine levels was specific to the M isoform of pyruvate kinase and that it depended on the ability of PKM2 to bind to ...
... pyruvate kinases . However , to confirm that the decrease in pyruvate kinase activity on increasing phosphotyrosine levels was specific to the M isoform of pyruvate kinase and that it depended on the ability of PKM2 to bind to ...
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activity adenovirus analysis antibody applications assay atoms binding Biol Biology cancer candidate carbon CD8 T cells Center complex correlation CP violation crystals cytosine desalination detected differentiation DNA methylation drug effect electron energy environment enzyme experiments function gene expression genetic genome human images increase infection Institute interactions isotopic ketyl Lett levels magnetic mantle measured mechanism MEFs membrane methylation mGluR2 mice microRNA midge molecular molecules mouse mRNA mutant Nature Nature Publishing Group Naturejobs neuronal observed online version paper at www.nature.com/nature pars tuberalis peptide peridotites phosphotyrosine photon Phys PKM2 plant plasmasphere population position predicted production protein pS2 promoter pyruvate kinase quantum receptor region regulation response ribosome role samples SATB1 says Science scientists sequence shown shRNA signal specific structure studies Supplementary Fig Supplementary Table target tion transcription tumour University vivo wild-type