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activity adaptation addition analysis applications approach areas associated authors binding biology cancer candidate cells Center changes complex correlation Department detected determined differentiation disease effect energy environment et al example experiments expression field Figure function funding further gene genetic genome growth Health human images important increase indicated Institute interactions interest involved lead levels light mantle March mean measured mechanism membrane Methods methylation mice molecular Nature observed organic performed physics plant population position possible potential predicted production promoter protein receptor reduced region regulation relative response REST role samples says Science scientific scientists selection sequence shown signal similar specific structure studies suggest Supplementary Fig tion University