Estrogens and Antiestrogens II: Pharmacology and Clinical Application of Estrogens and Antiestrogen

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Michael Oettel, Ekkehard Schillinger
Springer Science & Business Media, Dec 6, 2012 - Medical - 681 pages
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For many years, Springer has been publishing an impressive series of textbooks of pharmacology which have set standards in medical science. Surprisingly, an extensive overview of the current state of the art in research on estrogens and anti estrogens was still lacking. The present two volumes on estrogens and anti estrogens provide a comprehensive review of a field of research in which remarkable progress has been made over the past few years. New insights into the mechanisms of steroid hormone action resulted in a tremendous number of pUblications from which new principles of preventive and therapeutic appli cations of estrogens and anti estrogens emerged. Although various electronic data bases provide easy access to this copious information, there was a clear necessity for a monograph-style textbook which assesses and summarizes current knowledge in this rapidly expanding field of research. It should be noted, however, that, due to this dynamic development, it is barely possible to comprehensively update every aspect of basic and clinical knowledge on estro gens and antiestrogens. Thus, the intention of the editors was to provide the reader with an overview of the "classic" and most recently explored areas of research and stimulate future interests in basic and applied endocrinology. Estrogens were among the first steroid hormones described in the scientific literature. Since they were first isolated, since the chemical, synthesic and pharmacological characterization of naturally occurring estrogens and, later on, of orally active derivatives, estrogen research has produced continu ously hallmark results in reproductive endocrinology worldwide.
 

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Contents

CHAPTER 21
3
KUHL H Klinik für gynäkologische Endokrinologie Universitäts
9
Estrogen Effects on Expression of Endogenous Genes
26
Effects of ER Ligands on the Proliferation of
33
CHAPTER 22
95
G What is the Phenotype of ERB Knockout Mice
101
E Estrogen Effects on the Pancreas
107
B Pharmacological Effects of Exogenous Estrogens
121
Trichomoniasis
357
Conclusion
358
Immune System
359
ZIMMERMANN H Medical Research Department
363
Pharmacology of Contraceptive Steroids
369
F Use of Oral Contraceptives
380
Gastrointestinal Tract Disease
394
Endocrine Effects
395

KUIPER G Department of Medical Nutrition and Department
127
CHAPTER 25
129
G Blood Pressure
135
CHAPTER 26
141
References
147
NonGenomic Effects of Estrogens
150
B Estrogens and CNS
154
Conclusions
160
B Plasma Proteins
167
CHAPTER 29
179
Breast and Breast Cancer
185
G Conclusions
188
CHPATER 30
195
References
201
Clinical Implications and New Endocrine Agents
213
WINDING B Center for Clinical and Basic Research Ballerup Byvej 222
222
References
229
Estrogen Transforming Enzymes
231
Identification of the Active Pharmacophore Required
236
References
242
Conclusion
254
MAMMEN E F Department of Obstetrics and Gynecology
275
B Synthetic Estrogens
276
Influence of Age
302
Drug Interactions
303
References
304
CHAPTER 36
323
B Toxicology of Estrogens
325
Genotoxicity
329
Carcinogenicity
333
Reproductive Toxicity
336
Embryotoxicity
337
Perinatal and Postnatal Effects
339
Antiestrogens
340
Genotoxicity
341
Carcinogenicity
342
Reproductive Toxicity
343
CHAPTER 37
352
Human Immunodeficiency Virus Infection
354
Human Papillomavirus Infection
355
Candida Albicans Infection
356
Psychiatric Diseases
396
Stroke
397
Myocardial Infarction
398
Liver
399
Liver Tumors
400
Uterine Tumors
401
Ovarian Tumors
402
CHAPTER 39
408
Estrogens and the Skeleton
411
HRT Serum Lipids and the Risk of Cardiovascular Disease
415
Estrogens and Neurodegenerative Diseases
419
References
420
CHAPTER 40
423
Secondary Amenorrhoea
424
Bleeding Problems
426
E Antiestrogens
428
Physiology and Pathophysiology of Estrogens
438
CHAPTER 42
447
Oral Contraceptives and Thrombophilia
454
CHAPTER 43
461
CHAPTER 44
472
G Other Neuropsychiatric Disorders
488
CHAPTER 45
505
Metabolism and Pharmacokinetics of the Estrogens
513
F Liver
520
J The Influence of Environmental Estrogens Xenoestrogens
534
Steroidal Estrogens
542
The Therapeutic Value of Antiestrogens and Aromatase
544
References
551
CHAPTER 46
575
Evolution of Estrogen Functions
582
References
593
CHAPTER 47
603
E Dosage
608
Structures and Sources of Major Prototype Environmental
618
Mechanisms of Action
628
E Human Exposures Epidemiology and Potential Health
643
F Conclusion
651
485
665
505
674
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