Nucleic Acid Structure and Recognition
Oxford University Press, 2002 - Science - 188 pages
This book provides a detailed view of the molecular structures of DNA and RNA and how they are recognised by small molecules and proteins. Extensive source material is provided, including information on relevant web sites and computer programmes. The major methods of structural investigationfor nucleic acids: X-ray crystallography, NMR, and molecular modelling are reviewed and their scope and limitations (in the context of nucleic acids) discussed. Also covered are the conformational features of nucleic acid building blocks, including a description of how base-pair morphologies areanalysed; the structures of DNA double helices and helical oligonucleotides, emphasising current ideas on sequence-dependent structure; and DNA-DNA interactions, including triplexes and quadruplexes. The principles of RNA folding, ribosome, and ribozyme structure are also surveyed. Both covalent andnon-covalent nucleic acid interactions with small molecules are described, with the emphasis on recognition principles and sequence specific gene recognition. The principles of protein - nucleic acid are covered, focussing on regulatory proteins. Nucleic Acid Structure and Recognition will therefore equip readers with a good understanding of all the important aspects of this major field. The Nucleic Acid Database (NDB) crystallographic and NMR structures for the nucleic acid structures described in the book are freely available through the Nucleic Acid Structure and Recognition website.
What people are saying - Write a review
We haven't found any reviews in the usual places.
A-DNA A-RNA A-T base pairs Academy of Sciences adenine American Chemical Society analysis arrangement atoms B-DNA backbone conformation base triplets bending binding Biochemistry Biophysics complex covalently crystal structures crystallographic cytosine Dickerson–Drew dimer DNA sequence DNA structure dodecamer domain double helix drug duplex duplex DNA fibre diffraction function G-C base glycosidic angle guanine helical helical twist helix axis hydration hydrogen bonding interactions intercalation involved ions journal of Molecular large number ligand loop major methods minor groove mismatches Molecular Biology motif National Academy Neidle NMR structure NMR studies Nucleic Acid Structure Nucleic Acids Research nucleotides oligonucleotide oligonucleotide crystal overall parameters phosphate groups polynucleotide propeller twist proteins purine pyrimidine quadruplex recognition region residues resolution ribosome ribozyme Sciences USA sequence-dependent side chains stacking strand struc Structural Biology substituents sugar puckers thymine torsion angles tract transcription triplex tRNA water molecules Watson—Crick base pairing X-ray Z-DNA