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had afterwards been rubbed with a black substance. Beneath the nails thickening now began, so that some were raised an eighth of an inch. The edges also crumbled, but not with the same degree of irregularity as was noticed in the first named case.

At the time when the patient came under my observation, every nail on the hands was affected, except that of the left forefinger; the nails of the great toes were also diseased in a similar way. The nails were firmly fixed, to my sensation, when trying to move them ; but the patient said that they felt loose to her sensation, and that after soaking them in water they really were loose. Some of them were deeply cupped in the centre. I sent this patient to Mr. Orrin Smith for illustration. He has sketched four of the fingers with great care, together with a patch of the scaly eruption from the arm. The different drawings, given in the accompanying plate, show the nail-disease in various phases, and supply a description which could not be fully expressed in words.

I have only to add, that this patient, though a tall, delicate looking woman, had suffered little illness, and throughout life had been comfortably provided for.

A third example of this form of disease calls for the annexed observations. The patient was thirtyeight years old; a man actively engaged in business, and of genial disposition. He had become stout these last years, much too stout for his time of life, and very dyspeptic. His hair was grey, but firm. He had lived well at all times; and, without being intemperate, had habitually taken ante horam somni

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