Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications
Antioxidants inhibit the formation and spread of free radicals which can be damaging in biological systems. Free radicals form in biological systems through metabolism, but it is also realized that exogenous environmental sources, such as radiation, food, and drugs, contribute significantly to the generation of free radicals in biological systems. Being reactive species, free radicals are short-lived and do not travel far from cellular targets. Their concentration in biological systems is very low and is difficult to detect directly by electron spin resonance spectroscopy (ESR). Indirect methods of reactions of radicals with specific biomolecules are also sufficiently sensitive to detect quantitatively their presence. Thus the response of antioxidant defenses which react with radical species, can serve as an indirect measure that free radicals have been formed. Redox-based antioxidants change their oxidation state and antioxidants become free radicals themselves. Often, however, the antioxidants give rise to more persistent free radicals, sometimes owing to delocalization of the lone electron around ring structures (in vitamin E, ubiquinones, and certain carotenes). Persistent free radicals react only rarely and the precursors often can be regenerated in biological systems. In recent years, it is becoming clearer from biochemical studies on how the major lipophilic antioxidants work. Particular attention has been given to vitamin E and quinones found in animal and plant membranes and in carotenoids, for the protection of membranes in lipoprotein systems. Flavonoids form another rich and varied source of natural antioxidants
1 online resource (volumes)
9783034874342, 9783034874328, 3034874340, 3034874324
851741729
Printed edition
Vitamin E: Tocopherols and Tocotrienols and Ubiquinones
New horizons in vitamin E research
The vitamin E cycle, biochemistry, and clinical applications
The reactivity of tocotrienols and other lipid-soluble antioxidants towards peroxyl radicals
Physical/chemical studies of vitamin E in membranes
Synergistic effect of lipid hydroperoxyl radical scavenging and lipid hydroperoxide reduction in the inhibition of lipid peroxidation in biomembranes
Determination of rate constants for antioxidant activity and use of the crocin assay
Vitamin E in protection of oxidative impairment in endothelial and platelet functions
Antioxidant effectiveness of tocopherol isomers
Effect of vitamin E on metabolism of uremic low density lipoproteins in human monocyte-derived macrophage
Difference of antioxidative effect between vitamin E and selenium
Tocopherol and tocotrienol plasma transport and tissue concentrations: Implications for their relative biological functions
Modulation of cell proliferation by tocopherols and tocotrienols: Role in arteriosclerosis
Vitamin E and health in the marmoset monkey: A non-human primate model for nutritional research
Antitumor and antioxidant activity of tocotrienols
Tocopherols, carotenoids and the glutathione system
Nutrition of tocotrienols and lipid metabolism
Carotenoids, Flavonoids and Retinoids
Carotenoids and vitamin A: An overview
Metabolism of carotenoids by enzymes of oxygen metabolism
Role of?-carotene in disease prevention with special reference to cancer
Anti-tumor and anti-tumor promoting activity of?- and?-carotene
Production of palm oil carotenoid concentrate and its potential application in nutrition
Carotenoids, novel polyene polyketones and new capsorubin isomers as efficient quenchers of singlet molecular oxygen
Modification of alloxan diabetes in rats by vitamin A status
Flavonoids in foods: Their significance for nutrition and health
Studies on flavonoids and related compounds as antioxidants in food
Autocoid-immunopharmacology of flavonoids
Anticarcinogenicity of flavonoids as studied by inhibition of lipid peroxidation, microsomal degranulation and their interactions with benzo(a)pyrene metabolites
Role of retinoids in modulating the molecular actions of environmental carcinogens
Parasitic and Infectious Diseases
Free radicals and antioxidants in malaria
Oxygen free radicals in malaria
The mechanism of antimalarial action of artemisinin (Qinghaosu)
Erythrocytic GSH level and stability in Plasmodium vivax malaria
Plasma lipid peroxidation in P. falciparum malaria
Presence, formation and function of ubiquinones Q6 and Q8 in filarial parasites
Catalase activity in red cell and liver of mice infected with Plasmodium berghei
Clinical Applications. Antioxidant Therapy
The hypolipidaemic effect of different diets
Epidemiological correlations between poor plasma levels of essential antioxidants and the risk of coronary heart disease and cancer
Effect of different antioxidants in experimental myocardial infarction
Lipid-soluble plant phenols as antioxidants and anti-mutagens
Anti-cancer effects of cis-unsaturated fatty acids both in vitro and in vivo
Clinical studies on polyunsaturated fatty acids and antioxidants in African children
Dihydrolipoic acid is protective against reperfusion injury
Effect of japanese herbal medicine, Sho-saiko-to-go-keishi-kashakuyaku-to (TJ-960) on aging
Lipoprotein oxidation
Hepatic lipid peroxidation in ethanol potentiated aflatoxin B1 hepatotoxicity
Palm oil vitamin E effects in hypercholesterolemia
Fat soluble antioxidant vitamins in cancer patients
Butylated hydroxytoluene toxicity
Effects of tocotrienols-rich vitamin E on patients with peripheral vascular disease
Protection from air pollution injury by dietary vitamin E
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