Allergy and allergic diseases : the new mechanisms and therapeutics
In Allergy and Allergic Diseases: The New Mechanisms and Therapeutics, a distinguished international panel of researchers and clinicians review the latest findings on the cellular and molecular foundations of allergic diseases, particularly those of the airway, skin, and bowel. The key topics treated span the range from epidemiology and the mechanisms of inflammation, to signaling in pathogenesis and allergic reactions. Each contributor treats the pathophysiology of allergy in various organ-based diseases and syndromes, emphasizing important new findings from cellular and molecular biology that illuminate these diseases, but also reveal important leads for the development of novel drugs and therapeutic strategies. Allergy and Allergic Diseases: The New Mechanisms and Therapeutics highlights the interface between basic and clinical science in allergic disease. Its up-to-date, clinically relevant approach constitutes the new standard knowledge base in clinical immunology and allergy, not only for specialists, but also for internists, for scientists studying the cellular and molecular biology of inflammation and immunity, and for researchers focused on drug discovery and therapeutics. Authoritative and timely, Allergy and Allergic Diseases is clearly the today's indispensable new resource for all physicians and investigators seeking a deeper understanding of allergy in both its basic and clinical aspects
1 online resource (xvi, 591 pages) : illustrations
9781475727760, 9781617370267, 1475727763, 1617370266
607100447
I. Epidemiology/IgE
1 Molecular Mechanisms of Isotype Switching to IgE
2 Cytokines and IgE Regulation
3 Environmental Allergens
4 Ontogeny of Allergy
II. Inflammation: Cellular Aspects
5 The Role of the Bone Marrow in Allergic Disease
6 The Role of Mast Cells in Inflammation and Homeostatis
7 Human Langerhans Cells
8 Eosinophils
9 Role of Basophils in Allergic Reactions
10 Neurogenic Inflammation in Allergic Disease
11 Inflammation: Thl/Th2 Cells
12 T-Cells in the Pathogenesis of Asthma and Allergic Diseases
13 Role of CD8+ T-Cells in the Regulation of Immunoglobulin E
14 Airway Wall Structure
15 Epithelium
III. Inflammation: Molecular Aspects
16 Proinflammatory Cytokines in Allergic Disease
17 Hemopoietic Cytokines: Function, Receptors, and Signal Transduction
18 Adhesion Receptors in Allergic Disease
19 Cell/Cytokine Interactions
20 Signaling in Mast Cells
21 Signaling in Human Basophils
22 Eosinophil Signal Transduction
IV. Pathogenesis
23 Pathogenesis of Allergic Rhinitis
24 Pathogenic Mechanisms of Urticaria
25 Atopic Eczema
26 Pathogenesis of Asthma
27 Pathogenesis of Allergic Conjunctivitis
V. Therapeutics
28 Glucocorticoids (Corticosteroids)
29 Beta-Agonists
30 Sodium Cromoglycate and Nedocromil Sodium
31 Airway Remodeling and Repair
Electronic reproduction, [Place of publication not identified], HathiTrust Digital Library, 2010